(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

Base Information

Chemical Name:(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid
CAS No.:123125-28-0
Molecular Formula:C₂H₄O₂*C₁₉H₂₈N₂O₆
Molecular Weight:440.494
Hs Code.:

Synonyms:(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

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Chemical Property of (S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

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Technology Process of (S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

There total 12 articles about (S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3184-13-2,36630-89-4
L-ornithine hydrochloride

: 123125-28-0
(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) CuCO₃; 2.) NaHCO₃ / 1.) H₂O, 100 deg C, 1 h; 2.) 25 deg C, 24 h

2: Et₃N / dioxane; H₂O / 24 h / 25 °C

3: diethyl ether / 0.5 h / 0 °C

4: TFA / CH₂Cl₂ / 1 h / 0 °C

5: 2.) NaCNBH₃ / 1.) PhCH₃; 2.) CH₃OH, 25 deg C, 1 h

6: DMAP / 1,2-dichloro-ethane / 24 h / 70 °C

7: Zn / 2 h / 25 °C

With dmap; copper(II) carbonate; sodium cyanoborohydride; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; zinc; In 1,4-dioxane; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/ja00202a066

Reference yield:

: (S)-2-Amino-5-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-pentanoic acid

: 123125-28-0
(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / dioxane; H₂O / 24 h / 25 °C

2: diethyl ether / 0.5 h / 0 °C

3: TFA / CH₂Cl₂ / 1 h / 0 °C

4: 2.) NaCNBH₃ / 1.) PhCH₃; 2.) CH₃OH, 25 deg C, 1 h

5: DMAP / 1,2-dichloro-ethane / 24 h / 70 °C

6: Zn / 2 h / 25 °C

With dmap; sodium cyanoborohydride; triethylamine; trifluoroacetic acid; zinc; In 1,4-dioxane; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;
DOI:10.1021/ja00202a066

Reference yield:

: (S)-2-Amino-5-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-pentanoic acid methyl ester

: 123125-28-0
(S)-2-[Allyloxycarbonyl-(2,4-dimethoxy-benzyl)-amino]-5-amino-pentanoic acid methyl ester; compound with acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) NaCNBH₃ / 1.) PhCH₃; 2.) CH₃OH, 25 deg C, 1 h

2: DMAP / 1,2-dichloro-ethane / 24 h / 70 °C

3: Zn / 2 h / 25 °C

With dmap; sodium cyanoborohydride; zinc; In 1,2-dichloro-ethane;
DOI:10.1021/ja00202a066