[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

Base Information

Chemical Name:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone
CAS No.:1574110-75-0
Molecular Formula:C₂₄H₂₂ClF₃N₂O₃S
Molecular Weight:510.964
Hs Code.:

Synonyms:[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

There total 7 articles about [1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: (1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl)(thiomorpholino)methanone

: 1574110-75-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

Guidance literature:: With Oxone; In methanol; water; at 20 ℃;

Reference yield:

: 1574117-18-2
1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrole-2-carboxylic acid

: 1574110-75-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: Oxone / water; methanol / 20 °C

With Oxone; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; water;

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1574110-75-0
[1-benzyl-3-(4-chlorophenyl)-4-methyl-5-(trifluoromethyl)-1H-pyrrol-2-yl]-(1,1-dioxo-[1,4]-thiazinan-4-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: piperidine / toluene / 20 °C / Reflux; Dean-Stark

2.1: 1,5,7-triazabicyclo-[4,4,0]-dec-5-ene(TBD) polystyrene / tetrahydrofuran; isopropyl alcohol / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 20 °C

4.1: lithium hydroxide monohydrate; ethanol; water / tetrahydrofuran / 2 h / Reflux

5.1: ferrous(II) sulfate heptahydrate / dimethyl sulfoxide / 0.03 h

5.2: 1 h / 20 °C / Cooling

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

7.1: Oxone / water; methanol / 20 °C

With piperidine; ferrous(II) sulfate heptahydrate; Oxone; 1-hydroxy-7-aza-benzotriazole; lithium hydroxide monohydrate; ethanol; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;