dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

Base Information

Chemical Name:dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate
CAS No.:198700-45-7
Molecular Formula:C₁₇H₂₃NO₇
Molecular Weight:353.372
Hs Code.:

Synonyms:dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

There total 4 articles about dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 39684-80-5
2-(tert-butoxycarbonylamino)ethyl bromide

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 198700-45-7
dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

Guidance literature:: With caesium carbonate; sodium iodide; In butanone; at 70 ℃; for 8h;
DOI:10.1016/S0968-0896(98)00128-X

Reference yield: 71.0%

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 198700-45-7
dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 198700-45-7
dimethyl 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / diethylazodicarboxylate, triphenyl phosphine / tetrahydrofuran / 48 h / Ambient temperature

2: 1.) hydrazine hydrate, 2.) HCl / 1.) methanol, reflux -> room temperature, 2.) methanol, reflux -> room temperature

3: 71 percent / HCl / H₂O; dioxane

With hydrogenchloride; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/S0040-4020(97)00978-2