N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Base Information

Chemical Name:N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide
CAS No.:1307271-30-2
Molecular Formula:C₂₄H₃₁FN₆O₃S₂
Molecular Weight:534.679
Hs Code.:

Synonyms:N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Chemical Property of N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

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Technology Process of N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

There total 13 articles about N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1307271-96-0
1,1-dimethylethyl 4-(4-{2-fluoro-3-[(propylsulfonyl)amino]phenyl}-5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-1,3-thiazol-2-yl)-4-methyl-1-piperidinecarboxylate

: 1307271-30-2
N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

3-bromo-2-fluorobenzoic acid: 161957-56-8
3-bromo-2-fluorobenzoic acid

: 1307271-30-2
N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sulfuric acid / 1 h / Inert atmosphere; Reflux

2.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tert-butyl carbazate / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 90 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

4.2: 1.33 h / 0 - 20 °C / Inert atmosphere

5.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.83 h / 20 °C / Inert atmosphere

5.2: 0.5 h / 80 °C / Inert atmosphere

6.1: tri-n-butyl-tin hydride; water / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

8.1: toluene / 8 h / 90 °C / Inert atmosphere; Microwave irradiation

9.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; tert-butyl carbazate; sulfuric acid; water; tri-n-butyl-tin hydride; sodium hydrogencarbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; toluene;

Reference yield:

: 946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester

: 1307271-30-2
N-{2-fluoro-3-[5-{2-[(2-hydroxyethyl)amino]-4-pyrimidinyl}-2-(4-methyl-4-piperidinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrazine hydrate / tetrahydrofuran; methanol / 70 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -10 - 0 °C / Inert atmosphere

3.2: 1.33 h / 0 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 0.83 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 80 °C / Inert atmosphere

5.1: tri-n-butyl-tin hydride; water / bis-triphenylphosphine-palladium(II) chloride / dichloromethane / 1 h / 20 °C / Inert atmosphere

6.1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: toluene / 8 h / 90 °C / Inert atmosphere; Microwave irradiation

8.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; water; tri-n-butyl-tin hydride; sodium hydrogencarbonate; hydrazine hydrate; trifluoroacetic acid; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; dichloromethane; ISOPROPYLAMIDE; toluene;