2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

Base Information

Chemical Name:2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile
CAS No.:1372151-41-1
Molecular Formula:C₂₃H₂₄FN₃O₂
Molecular Weight:393.461
Hs Code.:

Synonyms:2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

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Chemical Property of 2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

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Technology Process of 2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

There total 9 articles about 2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1255207-10-3
5-(2-(piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one hydrochloride

: 1372151-51-3
2-fluoro-4-(2-oxoethyl)benzonitrile

: 1372151-41-1
2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

Guidance literature:: 5-(2-(piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one hydrochloride; 2-fluoro-4-(2-oxoethyl)benzonitrile; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 24h;

With hydrogenchloride; In diethyl ether; water; for 1h;
DOI:10.1021/ml3000066

Reference yield:

: 1255207-11-4
2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)acetaldehyde

: 1372151-41-1
2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 16 h / 20 °C

2.1: hydrogenchloride / 1,4-dioxane; water

3.1: triethylamine / dichloromethane / 0.5 h / 20 °C

3.2: 24 h / 20 °C

3.3: 1 h

With hydrogenchloride; sodium cyanoborohydride; acetic acid; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water;
DOI:10.1021/ml3000066

Reference yield:

: methyl 2-(3-fluoro-4-(((trifluoromethyl)sulfonyl)oxy)phenyl)acetate

: 1372151-41-1
2-fluoro-4-(2-(4-(2-(1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazin-1-yl)ethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

2.1: lithium borohydride / tetrahydrofuran / 12 h / 0 °C

3.1: Dess-Martin periodane / dichloromethane / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 20 °C

4.3: 1 h

With lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Dess-Martin periodane; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml3000066