3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

Base Information

Chemical Name:3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid
CAS No.:1202013-40-8
Molecular Formula:C₁₆H₁₁ClFN₃O₅
Molecular Weight:379.732
Hs Code.:

Synonyms:3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

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Chemical Property of 3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

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Technology Process of 3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

There total 11 articles about 3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202013-38-4
methyl 6-(acetyloxy)-3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-carboxylate

: 1202013-40-8
3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

Guidance literature:: methyl 6-(acetyloxy)-3-(3-chloro-4-fluorobenzyl)-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-8-carboxylate; With water; sodium hydroxide; In methanol; at 40 ℃; for 3h;

With hydrogenchloride; In methanol; water;

Reference yield:

: 709666-23-9
ethyl 3-[(tert-butoxycarbonyl)amino]-5-methoxyisonicotinate

: 1202013-40-8
3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 11 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: ethanol / 48 h / Reflux

3: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

4: peracetic acid; sodium acetate; acetic acid / 12 h / 20 °C

5: 0.33 h / 130 °C / Microwave irradiation

6: water; sodium hydroxide / methanol / 2 h / 20 °C

7: 2,6-dimethylpyridine; dmap / dichloromethane / 14 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 24 h / 80 °C / 15514.9 Torr

9: urea hydrogen peroxide adduct / methyltrioxorhenium(VII) / methanol; chloroform / 168 h / 20 °C

10: 2 h / 130 °C

11: water; sodium hydroxide / methanol / 3 h / 40 °C

With 2,6-dimethylpyridine; peracetic acid; dmap; water; sodium acetate; urea hydrogen peroxide adduct; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; palladium diacetate; methyltrioxorhenium(VII); In methanol; ethanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: pyrido[3,4-d]pyrimidin-4(3H)-one

: 1202013-40-8
3-(3-chloro-4-fluorobenzyl)-6-hydroxy-5-methoxy-4-oxo-3,4-dihydropyrido[3,4-d]pyrimidine-8-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: peracetic acid; sodium acetate; acetic acid / 12 h / 20 °C

3: 0.33 h / 130 °C / Microwave irradiation

4: water; sodium hydroxide / methanol / 2 h / 20 °C

5: 2,6-dimethylpyridine; dmap / dichloromethane / 14 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / palladium diacetate / dimethyl sulfoxide / 24 h / 80 °C / 15514.9 Torr

7: urea hydrogen peroxide adduct / methyltrioxorhenium(VII) / methanol; chloroform / 168 h / 20 °C

8: 2 h / 130 °C

9: water; sodium hydroxide / methanol / 3 h / 40 °C

With 2,6-dimethylpyridine; peracetic acid; dmap; water; sodium acetate; urea hydrogen peroxide adduct; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium diacetate; methyltrioxorhenium(VII); In methanol; dichloromethane; chloroform; dimethyl sulfoxide; N,N-dimethyl-formamide;