ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

Base Information

Chemical Name:ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate
CAS No.:1150103-17-5
Molecular Formula:C₁₅H₁₇N₃O₅S
Molecular Weight:351.383
Hs Code.:

Synonyms:ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

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Chemical Property of ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

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Technology Process of ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

There total 1 articles about ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 51767-39-6
4-(methylsulfonylamino)phenol

: 188781-08-0
2-chloro-4-methylpyrimidine-5-carboxylic acid ethyl ester

: 1150103-17-5
ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield: 42.0%

: 1150103-17-5
ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

: 1150103-18-6
N-(4-{[5-(hydroxymethyl)-4-methyl-2-pyrimidinyl]oxy}phenyl)methanesulfonamide

Guidance literature:: ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate; With diisobutylaluminium hydride; In dichloromethane; at -78 - 0 ℃; for 1.5h;

With water; rochelle salt; In dichloromethane; for 1h;

Reference yield:

: 1150103-17-5
ethyl 4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinecarboxylate

: 1150103-19-7
N-{4-[(5-formyl-4-methyl-2-pyrimidinyl)oxy]phenyl}methanesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane / -78 - 0 °C

2: manganese(IV) oxide / dichloromethane / 20 °C

With manganese(IV) oxide; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1016/j.bmcl.2011.08.080