5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

Base Information

Chemical Name:5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide
CAS No.:1150103-00-6
Molecular Formula:C₃₁H₃₃FN₈O₅S
Molecular Weight:648.718
Hs Code.:

5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

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Technology Process of 5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

There total 13 articles about 5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 1150103-19-7
N-{4-[(5-formyl-4-methyl-2-pyrimidinyl)oxy]phenyl}methanesulfonamide

: C₁₈H₂₀FN₅O₂*2ClH

: 1150103-00-6
5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

Guidance literature:: With sodium tris(acetoxy)borohydride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2011.08.080

Reference yield: 30.0%

: 1150103-00-6
5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

Guidance literature:

Reference yield:

: 125117-98-8
5-isocyanatopicolinonitrile

: 1150103-00-6
5-({[(3-fluorophenyl)(1-{[4-methyl-2-({4-[(methylsulfonyl)amino]phenyl}oxy)-5-pyrimidinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2-pyridinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 24 h

2: urea hydrogen peroxide adduct; potassium carbonate / water; acetone / 24 h / 20 °C

3: hydrogenchloride / 1,4-dioxane

4: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 20 °C

With hydrogenchloride; urea hydrogen peroxide adduct; sodium tris(acetoxy)borohydride; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2011.08.080