(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide

Base Information

• Chemical Name: (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide
• CAS No.: 1087058-28-3
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.322
• Mol file: 1087058-28-3.mol

Synonyms:(2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide

Chemical Property of (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide

There total 5 articles about (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

aniline (62-53-3) + piperic acid (136-72-1) → (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide (1087058-28-3)

Guidance literature:

piperic acid; With thionyl chloride; In dichloromethane; for 1h; Reflux;

aniline; In dichloromethane; for 1h;

DOI:10.1016/j.bmc.2008.09.042

Reference yield:

Piperine (94-62-2,7780-20-3) → (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide (1087058-28-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 24 h / 150 °C

2: thionyl chloride / dichloromethane / 2 h / Inert atmosphere; Cooling with ice

3: dichloromethane / 60 °C

With thionyl chloride; potassium hydroxide; In methanol; dichloromethane;

Reference yield:

piperic acid (136-72-1) → (2E,4E)-5-(3,4-methylenedioxyphenyl)-2,4-pentadienoic acid anilide (1087058-28-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 2 h / Inert atmosphere; Cooling with ice

2: dichloromethane / 60 °C

With thionyl chloride; In dichloromethane;

upstream raw materials:

aniline

piperic acid

piperic acid chloride

Piperine