t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

Base Information

Chemical Name:t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate
CAS No.:1349197-86-9
Molecular Formula:C₁₈H₂₆N₂O₆S
Molecular Weight:398.48
Hs Code.:

Synonyms:t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

Suppliers and Price of t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

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Technology Process of t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

There total 6 articles about t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1349197-85-8
(1S,4S)-5-(phenylsulfonyl)-2-oxa-5-azabicyclo[2.2.1]heptan-3-one

: 58620-93-2
tert-butyl 3-aminopropanoate hydrochloride

: 1349197-86-9
t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

Guidance literature:: With potassium carbonate; In water; toluene; at 80 ℃; for 2h;
DOI:10.1071/CH11204

Reference yield:

: 16257-76-4
1-(benzenesulphonyl)-4-hydroxypyrrolidine-2-carboxylic acid

: 1349197-86-9
t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / diethyl ether; water / 96 h / 20 °C

2: potassium carbonate / butanone / 2 h / Reflux

3: potassium carbonate / water; toluene / 2 h / 80 °C

With potassium carbonate; sodium hydroxide; In diethyl ether; water; toluene; butanone;
DOI:10.1071/CH11204

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1349197-86-9
t-butyl 3-((2S,4S)-4-hydroxy-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / water

2: sodium hydroxide / diethyl ether; water / 96 h / 20 °C

3: potassium carbonate / butanone / 2 h / Reflux

4: potassium carbonate / water; toluene / 2 h / 80 °C

With potassium carbonate; sodium hydroxide; In diethyl ether; water; toluene; butanone;
DOI:10.1071/CH11204