Technology Process of (R)-[(1R,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexyl]-(3,3-dimethyl-1,5,9-trioxa-spiro[5.5]undec-7-en-8-yl)-methanol
There total 33 articles about (R)-[(1R,2R,4S)-4-Benzyloxymethyl-2-(2-methoxy-ethoxymethoxy)-cyclohexyl]-(3,3-dimethyl-1,5,9-trioxa-spiro[5.5]undec-7-en-8-yl)-methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: (COCl)2
2: 1) nBuLi / 1) THF
3: 1) (Me2Si)2NLi / 1) THF, -78 deg C, 2) THF, -78 to 0 deg C
4: LiAlH4 / tetrahydrofuran
5: KH / tetrahydrofuran
6: 1) ozone
7: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO3 / hexane
8: Me2AlCl / CH2Cl2
10: ozone
11: 1) t-BuLi / 1) THF, 2) THF, HMPA
With
quinoline; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; (Me2Si)2NLi; hydrogen; tert.-butyl lithium; dimethylaluminum chloride; potassium hydride; ozone;
Lindlar's catalyst;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060
- Guidance literature:
-
Multi-step reaction with 7 steps
1: KH / tetrahydrofuran
2: 1) ozone
3: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO3 / hexane
4: Me2AlCl / CH2Cl2
6: ozone
7: 1) t-BuLi / 1) THF, 2) THF, HMPA
With
quinoline; hydrogen; tert.-butyl lithium; dimethylaluminum chloride; potassium hydride; ozone;
Lindlar's catalyst;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1) nBuLi / 1) THF
2: 1) (Me2Si)2NLi / 1) THF, -78 deg C, 2) THF, -78 to 0 deg C
3: LiAlH4 / tetrahydrofuran
4: KH / tetrahydrofuran
5: 1) ozone
6: 98 percent / hydrogen, quinoline / 5percent Pd/CaCO3 / hexane
7: Me2AlCl / CH2Cl2
9: ozone
10: 1) t-BuLi / 1) THF, 2) THF, HMPA
With
quinoline; lithium aluminium tetrahydride; n-butyllithium; (Me2Si)2NLi; hydrogen; tert.-butyl lithium; dimethylaluminum chloride; potassium hydride; ozone;
Lindlar's catalyst;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja00238a060
