amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester

Base Information

• Chemical Name: amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester
• CAS No.: 586413-53-8
• Molecular Formula: C₁₅H₂₅NO₃Si
• Molecular Weight: 295.454

Synonyms:amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester

Chemical Property of amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester

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Technology Process of amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester

There total 3 articles about amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycine methyl ester (586413-61-8) → amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester (586413-53-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/ja030249r

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester (586413-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 12 h

2: 116 mg / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja030249r

Reference yield:

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate (143323-49-3,141518-55-0) → amino-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-acetic acid methyl ester (586413-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: imidazole / dimethylformamide / 12 h

2: 116 mg / trifluoroacetic acid / CH₂Cl₂ / 2 h / 0 °C

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja030249r

upstream raw materials:

(R)-N-(t-butoxycarbonyl)-4-(t-butyldimethylsiloxy)phenylglycine methyl ester

tert-butyldimethylsilyl chloride

(R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate

Downstream raw materials:

C₄₃H₄₅Cl₂F₃N₄O₁₀Si

C₅₂H₆₇Cl₂IN₄O₁₁Si₂

C₅₉H₅₃Cl₄N₇O₁₄

C₄₈H₄₄Cl₄IN₅O₁₃

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