1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline

Base Information

• Chemical Name: 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline
• CAS No.: 100009-78-7
• Molecular Formula: C₂₀H₁₈N₂O₄
• Molecular Weight: 350.374
• Mol file: 100009-78-7.mol

Synonyms:1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline

Chemical Property of 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline

There total 5 articles about 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

copper(I) cyanide (544-92-3) + 1-(2'-bromo-4'-methoxyphenyl)-5,6,7-trimethoxy-3,4-dihydroisoquinoline (100009-80-1) → 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline (100009-78-7)

Guidance literature:

In N,N-dimethyl-formamide; at 180 ℃; for 5h;

DOI:10.1248/cpb.33.2778

Reference yield:

2-(2,3,4-trimethoxyphenyl)ethylamine (3937-16-4) → 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline (100009-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 86.9 percent / 10 percent NaOH / diethyl ether / 1 h / 0 °C

2: 90.2 percent / POCl₃ / toluene / 2.5 h / 120 - 140 °C / Heating

3: 89.2 percent / dimethylformamide / 5 h / 180 °C

With sodium hydroxide; trichlorophosphate; In diethyl ether; N,N-dimethyl-formamide; toluene;

DOI:10.1248/cpb.33.2778

Reference yield:

2-bromo-4-methoxybenzoic acid (74317-85-4) → 1-(2'-cyano-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline (100009-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂

2: 86.9 percent / 10 percent NaOH / diethyl ether / 1 h / 0 °C

3: 90.2 percent / POCl₃ / toluene / 2.5 h / 120 - 140 °C / Heating

4: 89.2 percent / dimethylformamide / 5 h / 180 °C

With sodium hydroxide; thionyl chloride; trichlorophosphate; In diethyl ether; N,N-dimethyl-formamide; toluene;

DOI:10.1248/cpb.33.2778

upstream raw materials:

copper(I) cyanide

1-(2'-bromo-4'-methoxyphenyl)-5,6,7-trimethoxy-3,4-dihydroisoquinoline

2-(2,3,4-trimethoxyphenyl)ethylamine

2-bromo-4-methoxybenzoic acid

Downstream raw materials:

1-(2'-methoxycarbonyl-4'-methoxyphenyl)-5,6,7-trimethoxyisoquinoline

dauriporphine

5-Methoxy-2-(5,6,7-trimethoxy-isoquinolin-1-yl)-benzoic acid

Refernces