4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

Base Information

Chemical Name:4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole
CAS No.:1359815-44-3
Molecular Formula:C₂₆H₂₄ClFN₂O₂
Molecular Weight:450.94
Hs Code.:

Synonyms:4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

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Chemical Property of 4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

Chemical Property:

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Technology Process of 4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

There total 6 articles about 4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

: 97566-69-3
3-fluoro-4-isopropoxyaniline

: 1359818-01-1
5-bromo-4-(4-chlorobenzyl)-2-benzyloxazole

: 1359815-44-3
4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 62088-10-2
4-(4-chloro-phenyl)-3-oxobutyric acid ethyl ester

: 1359815-44-3
4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate; hydroxylamine hydrochloride / ethanol / 2 h / Reflux

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / Cooling with ice; Reflux

3: acetone / 3 h / Photolysis; Inert atmosphere; Cooling with ice

4: N-Bromosuccinimide / chloroform / 1.5 h / 20 °C / Reflux

5: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; chloroform; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 1359818-00-0
4-(4-chlorobenzyl)-2-benzyloxazole

: 1359815-44-3
4-(4-chlorobenzyl)-2-benzyl-5-(3-fluoro-4-isopropoxyphenylamino)oxazole

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / chloroform / 1.5 h / 20 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; In chloroform; N,N-dimethyl-formamide;