4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

Base Information

Chemical Name:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid
CAS No.:1424279-68-4
Molecular Formula:C₁₉H₁₄Cl₂F₃NO₃
Molecular Weight:432.226
Hs Code.:

Synonyms:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

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Chemical Property of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

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Technology Process of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

There total 3 articles about 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1424279-67-3
t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

: 1424279-68-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 1424279-65-1
t-butyl 4-formyl-2-bromobenzoate

: 1424279-68-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol; water / 3 h / 10 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 4 h / 75 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1424279-64-0
tert-butyl 4-hydroxyiminomethyl-2-bromobenzoate

: 1424279-68-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 4 h / 75 °C

3.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;