t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

Base Information

Chemical Name:t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate
CAS No.:1424279-67-3
Molecular Formula:C₂₃H₂₂Cl₂F₃NO₃
Molecular Weight:488.334
Hs Code.:

Synonyms:t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

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Chemical Property of t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

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Technology Process of t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

There total 3 articles about t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 97-94-9
triethyl borane

: 1424279-66-2
t-butyl-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-bromobenzoate

: 1424279-67-3
t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In tetrahydrofuran; at 75 ℃; for 4h;

Reference yield:

: 1424279-65-1
t-butyl 4-formyl-2-bromobenzoate

: 1424279-67-3
t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol; water / 3 h / 10 - 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 4 h / 75 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; hydroxylamine hydrochloride; sodium acetate; caesium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1424279-64-0
tert-butyl 4-hydroxyiminomethyl-2-bromobenzoate

: 1424279-67-3
t-butyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-ethylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 4 h / 75 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-chloro-succinimide; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;