1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

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Chemical Name:1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate
CAS No.:1281969-42-3
Molecular Formula:C₂H₃O₂*C₃₁H₃₀F₃N₆O₂
Molecular Weight:634.658
Hs Code.:

1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

Synonyms:1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

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Chemical Property of 1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

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Technology Process of 1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

There total 3 articles about 1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1281969-43-4
5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-N-(2-pyrrolidin-1-ylethyl)-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide

: 631-61-8,92206-38-7
ammonium acetate

: 74-88-4
methyl iodide

: 1281969-42-3
1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

Guidance literature:: 5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-N-(2-pyrrolidin-1-ylethyl)-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide; methyl iodide; In acetonitrile; at 55 ℃;

ammonium acetate; In methanol; water; acetonitrile; for 0.5h;

Reference yield:

: 848140-72-7
ethyl 5-iodo-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxylate

: 1281969-42-3
1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogenphosphate trihydrate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 3 h / 55 °C

2.1: methanol / 0.67 h / 100 °C / Sealed; Microwave irradiation

3.1: acetonitrile / 55 °C

3.2: 0.5 h

With potassium hydrogenphosphate trihydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1150620-53-3
4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazol-1-yl]benzonitrile

: 1281969-42-3
1-{2-[({5-[1-(4-cyanophenyl)-1H-pyrazol-5-yl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridin-3-yl}carbonyl)amino]ethyl}-1-methylpyrrolidinium acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogenphosphate trihydrate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / N,N-dimethyl-formamide / 3 h / 55 °C

2.1: methanol / 0.67 h / 100 °C / Sealed; Microwave irradiation

3.1: acetonitrile / 55 °C

3.2: 0.5 h

With potassium hydrogenphosphate trihydrate; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); In methanol; N,N-dimethyl-formamide; acetonitrile;