2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

Base Information

Chemical Name:2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate
CAS No.:1563184-73-5
Molecular Formula:C₂₃H₃₈Br₂N₃O₉PS
Molecular Weight:723.417
Hs Code.:

Synonyms:2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

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Chemical Property of 2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

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Technology Process of 2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

There total 11 articles about 2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1563184-53-1
5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide

: 137348-86-8
di-tert-butyl diisopropylphosphoramide

: 1563184-73-5
2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

Guidance literature:: 5-(bis(2-bromoethyl)amino)-N-(2-hydroxyethyl)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamide; di-tert-butyl diisopropylphosphoramide; With 1H-tetrazole; In N,N-dimethyl-formamide; acetonitrile; at 5 - 20 ℃;

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃;

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 1563184-73-5
2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 10 steps

1.1: dimethyl sulfoxide / 3 h / 75 °C / Inert atmosphere

2.1: sodium dihydrogen phosphate monohydrate; dihydrogen peroxide; sodium chlorite; hydrogenchloride / acetonitrile; water / 0 - 20 °C

3.1: sulfuric acid; nitric acid / 4 h / 45 °C

4.1: perchloric acid / acetonitrile / 48 h / 20 °C

5.1: dimethyl sulfoxide / 2 h / 20 °C

6.1: triethylamine / dichloromethane / 0.33 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 5 - 20 °C

8.1: N,N-dimethyl-formamide; magnesium oxide; oxalyl dichloride / dichloromethane; acetonitrile / 4 h / 0 - 20 °C

8.2: 0.33 h / 0 - 20 °C

9.1: lithium bromide / acetone / 20 °C

10.1: 1H-tetrazole / acetonitrile; N,N-dimethyl-formamide / 5 - 20 °C

10.2: 0 - 20 °C

With 1H-tetrazole; hydrogenchloride; sodium chlorite; perchloric acid; sodium dihydrogen phosphate monohydrate; oxalyl dichloride; sulfuric acid; dihydrogen peroxide; nitric acid; magnesium oxide; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; lithium bromide; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 185945-90-8
5-fluoro-4-(methylsulfonyl)-2-nitrobenzoic acid

: 1563184-73-5
2-(5-(bis(2-bromoethyl)amino)-N-methyl-4-(methylsulfonyl)-2-nitrobenzamido)ethyl di-tert-butyl phosphate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 2 h / 45 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux

3.1: dichloromethane; tetrahydrofuran / 0.33 h / 0 °C

4.1: lithium bromide / Reflux

5.1: 1H-tetrazole / acetonitrile; N,N-dimethyl-formamide / 5 - 20 °C

5.2: 0 - 20 °C

With 1H-tetrazole; thionyl chloride; N,N-dimethyl-formamide; lithium bromide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;