Sun N8075 free base

Base Information

Chemical Name:Sun N8075 free base
CAS No.:224450-44-6
Molecular Formula:C₂₉H₃₆FN₃O₂
Molecular Weight:477.622
Hs Code.:
UNII:6X94HP0IIM
Nikkaji Number:J1.430.983G
Wikidata:Q76414605
ChEMBL ID:CHEMBL1183958

Synonyms:Sun N8075 free base;6X94HP0IIM;UNII-6X94HP0IIM;224450-44-6;CHEMBL325689;(alphaS)-alpha-((4-Amino-2,3,5-trimethylphenoxy)methyl)-4-(4-((4-fluorophenyl)methyl)phenyl)-1-piperazineethanol;1-Piperazineethanol, alpha-((4-amino-2,3,5-trimethylphenoxy)methyl)-4-(4-((4-fluorophenyl)methyl)phenyl)-, (alphaS)-;SCHEMBL3042761;CHEMBL1183958;BDBM50091591;(.ALPHA.S)-.ALPHA.-((4-AMINO-2,3,5-TRIMETHYLPHENOXY)METHYL)-4-(4-((4-FLUOROPHENYL)METHYL)PHENYL)-1-PIPERAZINEETHANOL;(2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-flourobenzyl)phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate(SUN N8075);(S)-1-(4-Amino-2,3,5-trimethylphenoxy)-3-[4-[4-(4-fluorobenzyl)phenyl]piperazine-1-yl]propane-2-ol;1-PIPERAZINEETHANOL, .ALPHA.-((4-AMINO-2,3,5-TRIMETHYLPHENOXY)METHYL)-4-(4-((4-FLUOROPHENYL)METHYL)PHENYL)-, (.ALPHA.S)-

Suppliers and Price of Sun N8075 free base

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Sun N8075 free base

Chemical Property:

XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:477.27915556
Heavy Atom Count:35
Complexity:615

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=C(C(=C1N)C)C)OCC(CN2CCN(CC2)C3=CC=C(C=C3)CC4=CC=C(C=C4)F)O
Isomeric SMILES:CC1=CC(=C(C(=C1N)C)C)OC[C@H](CN2CCN(CC2)C3=CC=C(C=C3)CC4=CC=C(C=C4)F)O

Technology Process of Sun N8075 free base

There total 8 articles about Sun N8075 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 301523-78-4
[4-(3-{4-[4-(4-fluoro-benzyl)-phenyl]-piperazin-1-yl}-2-hydroxy-propoxy)-2,3,6-trimethyl-phenyl]-carbamic acid tert-butyl ester

: 224450-44-6
(2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl}-2-propanol

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm000143w

Reference yield:

: 224449-73-4
(2S)-1-[(4-tert-butoxycarbonylamino-2,3,5-trimethyl)-phenoxy]-2,3-epoxypropane

: 224450-44-6
(2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl}-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / propan-2-ol / 6 h / Heating

2: TFA / CH₂Cl₂ / 2 h / 20 °C

With trifluoroacetic acid; In dichloromethane; isopropyl alcohol;
DOI:10.1021/jm000143w

Reference yield:

: 10486-46-1
2,3,5-Trimethyl-4-aminophenol

: 224450-44-6
(2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl)phenyl]-1-piperazinyl}-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / tetrahydrofuran / 2 h / 80 °C

2.1: NaH / dimethylformamide / 20 °C

2.2: 90 percent / dimethylformamide / 2 h / 20 °C

3.1: 90 percent / propan-2-ol / 6 h / Heating

4.1: TFA / CH₂Cl₂ / 2 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm000143w