N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride

Base Information

• Chemical Name: N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride
• CAS No.: 76005-13-5
• Molecular Formula: C₂₃H₂₆F₃N₅*2ClH
• Molecular Weight: 502.41

Synonyms:N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride

Chemical Property of N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride

Chemical Property:

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Technology Process of N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride

There total 4 articles about N²-(4-Dimethylamino-cyclohexyl)-N⁴-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

4-trifluoromethylphenylamine (455-14-1) + N'-(4-chloro-2-quinazolinyl)-N,N-dimethyl-1,4-cyclohexanediamine (76005-50-0) → N2-(4-Dimethylamino-cyclohexyl)-N4-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride (76005-13-5)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; for 3h; Heating;

DOI:10.1021/jm00134a002

Reference yield:

N1,N1-dimethylcyclohexane-1,4-diamine (42389-50-4) → N2-(4-Dimethylamino-cyclohexyl)-N4-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride (76005-13-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 25percent HCl / propan-2-ol; ethanol / 6 h / Heating

2: POCl₃ / 2 h / Heating

3: 75 percent / 25percent HCl / propan-2-ol / 3 h / Heating

With hydrogenchloride; trichlorophosphate; In ethanol; isopropyl alcohol;

DOI:10.1021/jm00134a002

Reference yield:

2-<<4-dimethylamino)cyclohexyl>amino>-4-quinazolinol (345229-18-7) → N2-(4-Dimethylamino-cyclohexyl)-N4-(4-trifluoromethyl-phenyl)-quinazoline-2,4-diamine; hydrochloride (76005-13-5)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / 2 h / Heating

2: 75 percent / 25percent HCl / propan-2-ol / 3 h / Heating

With hydrogenchloride; trichlorophosphate; In isopropyl alcohol;

DOI:10.1021/jm00134a002

upstream raw materials:

4-trifluoromethylphenylamine

N'-(4-chloro-2-quinazolinyl)-N,N-dimethyl-1,4-cyclohexanediamine

N¹,N¹-dimethylcyclohexane-1,4-diamine

2-<<4-dimethylamino)cyclohexyl>amino>-4-quinazolinol

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