(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide

Base Information

• Chemical Name: (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide
• CAS No.: 1428736-38-2
• Molecular Formula: C₁₇H₂₆N₂O₅
• Molecular Weight: 338.404

Synonyms:(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide

Chemical Property of (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide

Chemical Property:

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Technology Process of (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide

There total 1 articles about (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid (132970-18-4) → (2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide (1428736-38-2)

Guidance literature:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid; With chloroformic acid ethyl ester; triethylamine; In dichloromethane; at 0 ℃; for 0.116667h;

With ammonia; In dichloromethane; deuteromethanol; at 20 ℃; for 96h;

DOI:10.1016/j.tetasy.2013.02.007

Reference yield: 95.0%

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide (1428736-38-2) → (S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide (109522-07-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 8h; Reflux;

DOI:10.1016/j.tetasy.2013.02.007

Reference yield:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanamide (1428736-38-2) → (2R,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-51-9) + (2S,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one (1428736-52-0)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 8 h / Reflux

2: acetic acid / methanol / 12 h / Reflux

With acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.tetasy.2013.02.007

upstream raw materials:

(2S)-2-[(tert-butoxycarbonyl)amino]-2-methyl-3-(3,4-dimethoxyphenyl)propanoic acid

Downstream raw materials:

(S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide

(2R,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one

(2S,5S)-5-(3,4-dimethoxybenzyl)-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one

(2R,5S)-5-(3,4-dimethoxybenzyl)-2,5-dimethyl-2-(pyridine-2-yl)imidazolidine-4-one

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