1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

Base Information

Chemical Name:1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester
CAS No.:1448312-75-1
Molecular Formula:C₂₈H₄₀N₂O₄
Molecular Weight:468.637
Hs Code.:

Synonyms:1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

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Chemical Property of 1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

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Technology Process of 1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

There total 5 articles about 1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1448312-74-0
2(R)-(2(S)-amino-3-phenylpropyl)-3(S)-benzylaziridine-1-carboxylic acid benzyl ester

: 1448312-75-1
1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

: (1R,4R)-N-(1-benzyl-4-benzyloxycarbonylamino-5-phenylpentyl)-t-butylcarbamate

Guidance literature:: 2(R)-(2(S)-amino-3-phenylpropyl)-3(S)-benzylaziridine-1-carboxylic acid benzyl ester; With palladium 10% on activated carbon; hydrogen; In ethanol; water; under 2585.81 Torr; Inert atmosphere;

di-tert-butyl dicarbonate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 48h;

Reference yield:

: 1448312-65-9
1,6-diphenyl-5(S)-tert-butoxycarbonylamino-3(S)-hydroxy-2(S)-phenylmethoxy-carbonylaminohexane

: 1448312-75-1
1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

: (1R,4R)-N-(1-benzyl-4-benzyloxycarbonylamino-5-phenylpentyl)-t-butylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / -20 - 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / -20 - 0 °C

4.1: palladium 10% on activated carbon; hydrogen / water; ethanol / 2585.81 Torr / Inert atmosphere

4.2: 48 h

With pyridine; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 144163-85-9
(2S,3S,5S)-2-amino-3-hydroxy-5-(t-butyloxycarbonylamino)-1,6-diphenylhexane

: 1448312-75-1
1,6-diphenyl-2(R)-(t-butoxycarbonyl)amino-4(S)-carbamic acid t-butyl ester

: (1R,4R)-N-(1-benzyl-4-benzyloxycarbonylamino-5-phenylpentyl)-t-butylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 0 - 20 °C

2.1: pyridine / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / -20 - 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / -20 - 0 °C

5.1: palladium 10% on activated carbon; hydrogen / water; ethanol / 2585.81 Torr / Inert atmosphere

5.2: 48 h

With pyridine; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;