2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

Base Information

Chemical Name:2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine
CAS No.:86422-02-8
Molecular Formula:C₁₅H₁₅Cl₂NO₃
Molecular Weight:328.195
Hs Code.:

Synonyms:2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

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Technology Process of 2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

There total 5 articles about 2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86421-99-0
dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

: 86422-02-8
2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1021/jm00363a023

Reference yield:

: 86421-96-7
N-(3,4-dichlorobenzoyl)-4-hydroxy-L-proline

: 86422-02-8
2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 48 h / Ambient temperature

2: acetic anhydride / 1 h / Heating

3: HCl gas / methanol / 96 h / Ambient temperature

4: 85 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; lithium aluminium tetrahydride; acetic anhydride; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00363a023

Reference yield:

: 86421-97-8
(2S,4R)-4-Acetoxy-1-(3,4-dichloro-benzoyl)-pyrrolidine-2-carboxylic acid

: 86422-02-8
2-hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride / 1 h / Heating

2: HCl gas / methanol / 96 h / Ambient temperature

3: 85 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / 0.5 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; acetic anhydride; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/jm00363a023