dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

Base Information

Chemical Name:dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate
CAS No.:86421-99-0
Molecular Formula:C₁₇H₁₅Cl₂NO₅
Molecular Weight:384.216
Hs Code.:

Synonyms:dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

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Chemical Property of dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

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Technology Process of dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

There total 5 articles about dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86421-98-9
(R)-6-Acetoxy-3-(3,4-dichloro-phenyl)-6,7-dihydro-5H-pyrrolizine-1,2-dicarboxylic acid dimethyl ester

: 86421-99-0
dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: With hydrogenchloride; In methanol; for 96h; Yield given; Ambient temperature;
DOI:10.1021/jm00363a023

Reference yield:

: 86421-96-7
N-(3,4-dichlorobenzoyl)-4-hydroxy-L-proline

: 86421-99-0
dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 48 h / Ambient temperature

2: acetic anhydride / 1 h / Heating

3: HCl gas / methanol / 96 h / Ambient temperature

With pyridine; hydrogenchloride; acetic anhydride; In methanol;
DOI:10.1021/jm00363a023

Reference yield:

: 86421-97-8
(2S,4R)-4-Acetoxy-1-(3,4-dichloro-benzoyl)-pyrrolidine-2-carboxylic acid

: 86421-99-0
dimethyl 5-(3,4-dichlorophenyl)-2-hydroxy-2,3-dihydro-1H-pyrrolizine-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic anhydride / 1 h / Heating

2: HCl gas / methanol / 96 h / Ambient temperature

With hydrogenchloride; acetic anhydride; In methanol;
DOI:10.1021/jm00363a023