2-Bromo-2-methyl-1-morpholinopropan-1-one

Base Information

• Chemical Name: 2-Bromo-2-methyl-1-morpholinopropan-1-one
• CAS No.: 13887-51-9
• Molecular Formula: C₈H₁₄BrNO₂
• Molecular Weight: 236.109
• DSSTox Substance ID: DTXSID10548903
• Nikkaji Number: J2.311.220E
• Wikidata: Q82427754

Synonyms:2-BROMO-2-METHYL-1-MORPHOLINOPROPAN-1-ONE;13887-51-9;2-Bromo-2-methyl-1-(morpholin-4-yl)propan-1-one;2-bromo-2-methyl-1-morpholin-4-ylpropan-1-one;DTXSID10548903;MFCD12910756;AKOS022548744;AS-31832;CS-0171672;2-Bromo-2-methyl-1-morpholin-4-yl-propan-1-one;A921493;A1-13436

Chemical Property of 2-Bromo-2-methyl-1-morpholinopropan-1-one

Chemical Property:

• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 235.02079
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-2-Methyl-1-Morpholinopropan-1-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C(=O)N1CCOCC1)Br

Technology Process of 2-Bromo-2-methyl-1-morpholinopropan-1-one

There total 1 articles about 2-Bromo-2-methyl-1-morpholinopropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + 2-bromoisobutyric acid bromide (20769-85-1) → 2-bromo-2-methyl-1-morpholinopropan-1-one (13887-51-9)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ja056076i

Reference yield: 97.0%

1-bromo-4-methoxy-benzene (104-92-7) + 2-bromo-2-methyl-1-morpholinopropan-1-one (13887-51-9) → 2-(4-methoxy-phenyl)-2-methyl-1-morpholin-4-yl-propan-1-one

Guidance literature:

2-bromo-2-methyl-1-morpholinopropan-1-one; With zinc; In tetrahydrofuran; at 20 ℃; for 0.5h;

1-bromo-4-methoxy-benzene; With {[P(t-Bu)3]PdBr}2; In tetrahydrofuran; toluene; at 20 ℃; for 12h;

DOI:10.1021/ja056076i

Reference yield: 93.0%

2-bromo-2-methyl-1-morpholinopropan-1-one (13887-51-9) + 1-bromo-4-tert-butylbenzene (3972-65-4) → 2-(4-tert-butyl-phenyl)-2-methyl-1-morpholin-4-yl-propan-1-one

Guidance literature:

2-bromo-2-methyl-1-morpholinopropan-1-one; With zinc; In tetrahydrofuran; at 20 ℃; for 0.5h;

1-bromo-4-tert-butylbenzene; With {[P(t-Bu)3]PdBr}2; In tetrahydrofuran; toluene; at 20 ℃; for 12h;

DOI:10.1021/ja056076i

upstream raw materials:

morpholine

2-bromoisobutyric acid bromide

Downstream raw materials:

4-{3-[N-(2-hydroxy-ethyl)-anilino]-2,2-dimethyl-propionyl}-morpholine

4-(2,2-dimethyl-3-phenyl-3-piperidin-1-yl-propionyl)-morpholine

4-(3-anilino-2,2-dimethyl-3-phenyl-propionyl)-morpholine

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