Technology Process of (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-methylpiperidine
There total 10 articles about (3S,4S,5R)-N-tert-butoxycarbonyl-3-(tert-butyldiphenylsilyloxy)-4-hydroxy-5-methylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
diethyl ether;
at -78 ℃;
for 2h;
DOI:10.1021/jo050519j
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 49 percent / Pseudomonas cepacia lipase/ceramics / various solvent(s) / 18 h / 40 °C
2: 98 percent / Pseudomonas cepacia lipase/ceramics; aq. phosphate buffer / acetone / 18 h / 40 °C / pH 7.0
3: 99 percent / imidazole; DMAP / CH2Cl2 / 3 h / 20 °C
4: 72 percent / oxone; aq. Na2EDTA; CF3COCH3 / NaHCO3 / acetonitrile / 0 °C
5: 71 percent / BF3*Et2O; CuCN / diethyl ether / 2 h / -78 °C
With
1H-imidazole; dmap; Oxone; phosphate buffer; Pseudomonas cepacia lipase; 1,1,1-trifluoro-2-propanone; ceramics; boron trifluoride diethyl etherate; edetate disodium;
sodium hydrogencarbonate;
In
diethyl ether; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jo050519j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / imidazole; DMAP / CH2Cl2 / 3 h / 20 °C
2: 72 percent / oxone; aq. Na2EDTA; CF3COCH3 / NaHCO3 / acetonitrile / 0 °C
3: 71 percent / BF3*Et2O; CuCN / diethyl ether / 2 h / -78 °C
With
1H-imidazole; dmap; Oxone; 1,1,1-trifluoro-2-propanone; boron trifluoride diethyl etherate; edetate disodium;
sodium hydrogencarbonate;
In
diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/jo050519j
