224779-27-5

Basic information

• Product Name: N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE
• Synonyms: N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE;3-HYDROXY-3,6-DIHYDRO-2H-PYRIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-3-hydroxy-1,2,3,6-tetrahydro-pyridine;3-Hydroxy-1,2,3,6-tetrahydropyridine, N-BOC protected;tert-Butyl 3-hydroxy-1,2,3,6-tetrahydropyridine-1-carboxylate;tert-Butyl 3,6-dihydro-3-hydroxypyridine-1(2H)-carboxylate;tert-Butyl 3,6-dihydro-3-hydroxypyridine-1(2H)-carboxylate, 1-(tert-Butoxycarbonyl)-3-hydroxy-1,2,3,6-tetrahydropyridine;tert-Butyl 5-hydroxy-5,6-dihydropyridine-1(2H)-carboxylate
• CAS NO: 224779-27-5
• Molecular Formula: C₁₀H₁₇NO₃
• Molecular Weight: 199.25
• Mol File: 224779-27-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 55-56 °C(Solv: hexane (110-54-3))
• Boiling Point: 295.9°Cat760mmHg
• Flash Point: 132.8°C
• Appearance: /
• Density: 1.138g/cm³
• Vapor Pressure: 0.000153mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.17±0.20(Predicted)
• CAS DataBase Reference: N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE(224779-27-5)
• EPA Substance Registry System: N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE(224779-27-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 224779-27-5(Hazardous Substances Data)

Usage

Uses

1-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine is used as pharmaceutical intermediate.

InChI:InChI=1/C10H17NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h4-5,8,12H,6-7H2,1-3H3

Upstream product

• 85838-94-4 N-Boc-1,2,3,6-tetrahydropyridine 

Downstream Products

• 1189166-13-9 C₂₀H₂₇N₃O₄S 
• 1189166-12-8 C₂₁H₂₇N₃O₅S 
• 1189166-04-8 2-(4-dimethylamino-phenyl)-7-hydroxy-6,7-dihydro-4H-thiazolo[4,5-c][1,3]pyridine-5-carboxylic acid tert-butyl ester 
• 1189165-85-2 2-(2-hydroxymethyl-4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridine-7-ol 
• 1189165-79-4 (R)-2-(4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ol 
• 1189165-81-8 (S)-2-(4-dimethylamino-phenyl)-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ol 
• 1189165-77-2 2-[4-(dimethylamino)phenyl]-4,5,6,7-tetrahydro[1,3]thiazolo[4,5-c]pyridin-7-ol 

Relevant articles and documents

SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted cyclic compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.