4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

Base Information

Chemical Name:4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide
CAS No.:483305-04-0
Molecular Formula:C₁₆H₂₅ClN₄O₄S
Molecular Weight:404.918
Hs Code.:

Synonyms:4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

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Chemical Property of 4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

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Technology Process of 4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

There total 5 articles about 4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 206434-34-6
(RS)-6-amino-1-ethyl-4-methylhexahydro-1,4-diazepine

: 55524-67-9
4-chloro-2-methoxy-5-sulfamoylbenzoic acid

: 483305-04-0
4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1248/cpb.50.941

Reference yield:

: 111-37-5
N-methyl-N'-ethylethane-1,2-diamine

: 483305-04-0
4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 3 h / 5 °C

1.2: 46 percent / NaBH₄ / methanol / 16 h / 20 °C

2.1: 88 percent / HBr / acetic acid / 1 h / 20 °C

3.1: 62 percent / EDC / CH₂Cl₂ / 4 h / 20 °C

With hydrogen bromide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; dichloromethane; acetic acid;
DOI:10.1248/cpb.50.941

Reference yield:

: 57479-73-9
4-chloro-5-chlorosulfonyl-2-methoxybenzoic acid

: 483305-04-0
4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 28 percent aq. NH₃ / 2 h / 40 - 50 °C

2: 62 percent / EDC / CH₂Cl₂ / 4 h / 20 °C

With ammonium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1248/cpb.50.941