4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid

Base Information

• Chemical Name: 4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid
• CAS No.: 55524-67-9
• Molecular Formula: C8H8ClNO5S
• Molecular Weight: 265.67082
• Hs Code.: 2935009090
• Mol file: 55524-67-9.mol

Synonyms:4-chloro-2-methoxy-5-methylphenylhydrazine;

Chemical Property of 4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid

Chemical Property:

• PSA: 115.07000
• LogP: 2.47530
• Storage Temp.: 2-8°C

Purity/Quality:

4-Chloro-2-methoxy-5-sulfamoylbenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid

There total 2 articles about 4-Chloro-2-Methoxy-5-sulfaMoylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-chloro-5-chlorosulfonyl-2-methoxybenzoic acid (57479-73-9) → 4-chloro-2-methoxy-5-sulfamoylbenzoic acid (55524-67-9)

Guidance literature:

With ammonium hydroxide; at 40 - 50 ℃; for 2h;

DOI:10.1248/cpb.50.941

Reference yield:

2-methoxy-4-chlorobenzoic acid (57479-70-6) → 4-chloro-2-methoxy-5-sulfamoylbenzoic acid (55524-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / ClSO₃H / 2 h / 60 - 70 °C

2: 89 percent / 28 percent aq. NH₃ / 2 h / 40 - 50 °C

With chlorosulfonic acid; ammonium hydroxide;

DOI:10.1248/cpb.50.941

Reference yield: 62.0%

(RS)-6-amino-1-ethyl-4-methylhexahydro-1,4-diazepine (206434-34-6) + 4-chloro-2-methoxy-5-sulfamoylbenzoic acid (55524-67-9) → 4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide (483305-04-0)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1248/cpb.50.941

upstream raw materials:

4-chloro-5-chlorosulfonyl-2-methoxybenzoic acid

2-methoxy-4-chlorobenzoic acid

Downstream raw materials:

4-chloro-N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)-2-methoxy-5-sulfamoylbenzamide

Refernces