[(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone

Base Information

• Chemical Name: [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone
• CAS No.: 97204-13-2
• Molecular Formula: C₃₂H₂₄N₂O₄
• Molecular Weight: 500.554
• Mol file: 97204-13-2.mol

Synonyms:[(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone

Chemical Property of [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone

There total 7 articles about [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-nitrobenzyl)isoquinolinium bromide (16726-82-2) + 1,4-diphenylbut-2-ene-1,4-dione (959-28-4) → [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone (97204-13-2)

Guidance literature:

With triethylamine; In acetonitrile; for 12h; Ambient temperature;

DOI:10.1246/bcsj.58.3137

Reference yield: 100.0%

C16H12N2O2 + 1,4-diphenylbut-2-ene-1,4-dione (959-28-4) → [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone (97204-13-2)

Guidance literature:

In acetonitrile; for 12h; Ambient temperature;

DOI:10.1246/cl.1985.355

Reference yield:

(Z)-1,4-diphenylbut-2-ene-1,4-dione (959-27-3) → [(1S,2S,3S,10bR)-2-Benzoyl-3-(4-nitro-phenyl)-1,2,3,10b-tetrahydro-pyrrolo[2,1-a]isoquinolin-1-yl]-phenyl-methanone (97204-13-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / triethylamine / CHCl₃ / 0.17 h / Ambient temperature

2: dimethylsulfoxide-d6 / 1 h / 50 - 60 °C

3: dimethylsulfoxide-d6 / 24 h / 50 - 60 °C

4: 100 percent / triethylamine / acetonitrile / 12 h / Ambient temperature

With triethylamine; In dimethylsulfoxide-d6; chloroform; acetonitrile;

DOI:10.1246/bcsj.58.3137

upstream raw materials:

2-(4-nitrobenzyl)isoquinolinium bromide

1,4-diphenylbut-2-ene-1,4-dione

(Z)-1,4-diphenylbut-2-ene-1,4-dione

2-phenacylisoquinolinium bromide