(+/-)-SJ₃₁₂₅₆₁ hydrochloride

Base Information

• Chemical Name: (+/-)-SJ₃₁₂₅₆₁ hydrochloride
• CAS No.: 1295470-24-4
• Molecular Formula: C₂₉H₃₃NO₃*ClH
• Molecular Weight: 480.047
• Mol file: 1295470-24-4.mol

Synonyms:(+/-)-SJ₃₁₂₅₆₁ hydrochloride

Chemical Property of (+/-)-SJ₃₁₂₅₆₁ hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-SJ₃₁₂₅₆₁ hydrochloride

There total 3 articles about (+/-)-SJ₃₁₂₅₆₁ hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-phenylpiperidine (771-99-3) + 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one (22525-95-7) → (+/-)-SJ312561 hydrochloride (1295470-24-4)

Guidance literature:

4-phenylpiperidine; 1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one; In ethanol; at 160 ℃; for 0.25h; Microwave irradiation;

With hydrogenchloride; In methanol;

DOI:10.1021/jm2005546

Reference yield: 90.0%

1‐(2‐(2‐hydroxy‐3‐(4‐phenylpiperidine‐1‐yl)propoxy)phenyl)‐3‐phenylpropan‐1‐one → (+/-)-SJ312561 hydrochloride (1295470-24-4)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/ardp.201900269

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → (+/-)-SJ312561 hydrochloride (1295470-24-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 18 h / Reflux

2: ethanol / 0.25 h / 160 °C / Microwave irradiation

With sodium hydroxide; In ethanol;

DOI:10.1021/jm2005546

upstream raw materials:

4-phenylpiperidine

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

2'-hydroxy-3-phenylpropiophenone