ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Base Information

Chemical Name:ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate
CAS No.:1268383-42-1
Molecular Formula:C₂₈H₂₂F₅N₅O₄
Molecular Weight:587.506
Hs Code.:

Synonyms:ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Chemical Property of ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

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Technology Process of ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

There total 6 articles about ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1105058-57-8
2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazine

: 1268385-37-0
ethyl bromo{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

: 1268383-42-1
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1268385-33-6
{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

: 1268383-42-1
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1234790-81-8
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde

: 1268383-42-1
ethyl [2-(2,3-difluorophenyl)-5H-imidazo[4,5-d]pyridazin-5-yl]{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydroxylamine / ethanol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

2.2: Reflux

3.1: periodic acid / acetonitrile / 0 - 20 °C

3.2: 0 - 20 °C

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

5.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 18 h / Reflux

6.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

With dmap; N-chloro-succinimide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydroxylamine; potassium carbonate; periodic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;