{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

Base Information

Chemical Name:{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid
CAS No.:1268385-33-6
Molecular Formula:C₁₅H₁₄F₃NO₄
Molecular Weight:329.276
Hs Code.:

Synonyms:{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

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Chemical Property of {3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

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Technology Process of {3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

There total 5 articles about {3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1268385-32-5
2-{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol

: 1268385-33-6
{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

Guidance literature:: 2-{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-ethanol; With periodic acid; In acetonitrile; at 0 - 20 ℃;

With pyridinium chlorochromate; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 1234790-83-0
4-(propyloxy)-2-(trifluoromethyl)benzaldehyde oxime

: 1268385-33-6
{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 °C

1.2: Reflux

2.1: periodic acid / acetonitrile / 0 - 20 °C

2.2: 0 - 20 °C

With N-chloro-succinimide; periodic acid; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₁₁H₁₁ClF₃NO₂

: 1268385-33-6
{3-[4-(propyloxy)-2-(trifluoromethyl)phenyl]-5-isoxazolyl}-acetic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,2-dichloro-ethane / 2 h / Inert atmosphere

2: pyridinium chlorochromate; periodic acid / acetonitrile / 3 h / 20 °C / Cooling with ice; Inert atmosphere

With periodic acid; triethylamine; pyridinium chlorochromate; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jo4014595