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Base Information Edit
  • Chemical Name:Trimethylchlorosilane
  • CAS No.:75-77-4
  • Deprecated CAS:127290-36-2,36642-33-8
  • Molecular Formula:C3H9ClSi
  • Molecular Weight:108.643
  • Hs Code.:29310095
  • European Community (EC) Number:200-900-5
  • ICSC Number:0966
  • NSC Number:15750
  • UN Number:1298
  • UNII:62UO4690X6
  • DSSTox Substance ID:DTXSID2024822
  • Nikkaji Number:J1.466D
  • Wikipedia:Trimethylsilyl_chloride
  • Wikidata:Q420183
  • ChEMBL ID:CHEMBL1505385
  • Mol file:75-77-4.mol


Suppliers and Price of Trimethylchlorosilane
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Chlorotrimethylsilane
  • 100g
  • $ 155.00
  • TCI Chemical
  • Chlorotrimethylsilane >98.0%(GC)
  • 100mL
  • $ 19.00
  • TCI Chemical
  • Chlorotrimethylsilane >98.0%(GC)
  • 25mL
  • $ 16.00
  • TCI Chemical
  • Chlorotrimethylsilane >98.0%(GC)
  • 500mL
  • $ 43.00
  • SynQuest Laboratories
  • Trimethylchlorosilane 99%
  • 1 L
  • $ 64.00
  • SynQuest Laboratories
  • Trimethylchlorosilane 99%
  • 250 mL
  • $ 24.00
  • Strem Chemicals
  • Trimethylchlorosilane, min. 97%
  • 500g
  • $ 131.00
  • Strem Chemicals
  • Trimethylchlorosilane, min. 97%
  • 100g
  • $ 40.00
  • Soltec Ventures
  • Trichloromethylsilane,99+% 99+%
  • 10
  • $ 5.04
  • Sigma-Aldrich
  • Chlorotrimethylsilane produced by Wacker Chemie AG, Burghausen, Germany, ≥99.0% (GC)
  • 25kg-f
  • $ 1270.00
Total 157 raw suppliers
Chemical Property of Trimethylchlorosilane Edit
Chemical Property:
  • Appearance/Colour:colourless liquid 
  • Vapor Pressure:100 mm Hg ( 25 °C) 
  • Melting Point:-40 °C(lit.) 
  • Refractive Index:n20/D 1.500  
  • Boiling Point:58.737 °C at 760 mmHg 
  • Flash Point:-18 °C 
  • PSA:0.00000 
  • Density:0.868 g/cm3 
  • LogP:2.06010 
  • Storage Temp.:Store at RT. 
  • Sensitive.:Moisture Sensitive 
  • Solubility.:Miscible with ether, benzene, diethylether and perchloroethylene 
  • Water Solubility.:REACTS 
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:0
  • Rotatable Bond Count:0
  • Exact Mass:108.0162045
  • Heavy Atom Count:5
  • Complexity:28.4
  • Transport DOT Label:Flammable Liquid Corrosive

98% *data from raw suppliers

Chlorotrimethylsilane *data from reagent suppliers

Safty Information:
  • Pictogram(s): FlammableF,Corrosive
  • Hazard Codes:T,F,C,Xn 
  • Statements: 20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52 
  • Safety Statements: 26-36/37/39-45-16-36/37-7/9 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

  • Chemical Classes:Toxic Gases & Vapors -> Chlorosilanes
  • Canonical SMILES:C[Si](C)(C)Cl
  • Inhalation Risk:No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20 °C.
  • Effects of Short Term Exposure:The substance and the vapour are corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. Exposure could cause death. Medical observation is indicated.
  • Description Chlorotrimethylsilane is a valuable reagent for the protection of the hydroxyl function in organic synthesis. It should be distilled from calciumhydride (or tributylamine) under nitrogen before use,and stored and weighed under nitrogen. Use of the reagent without purification has been reported to lead to explosions. Chlorotrimethylsilane may contain dichlorodimethylsilane as an impurity. This may be removed before distillation by very cautious treatment with a small amount of water,which hydrolyses the dichloro compound more rapidly. Excess chlorotrimethylsilane in a reaction mixture may be destroyed by the very careful addition of aqueous sodium hydrogencarbonate solution.
  • Uses Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis. It is used in the production of trimethylsilyl halides, pseudohalides and various organic silicon compounds. It is also used to produce hexamethyldisilane by reduction.
Technology Process of Trimethylchlorosilane

There total 957 articles about Trimethylchlorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With hydrogenchloride; In tetrahydrofuran; mixt. od dry HCl (excess), Pr/Sn-complex and THF keeping dor 1 d at room temp., THF replacing by hexane in usual way; ppt. filtration of, hexane-soln. evapn. (vac.), residue crystn. twice (hexane, -70°C), GLC of volatiles;
Guidance literature:
With phosphorus pentachloride; In tetrachloromethane; for 1h; Ambient temperature;
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