4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

Base Information

Chemical Name:4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester
CAS No.:448961-56-6
Molecular Formula:C₃₄H₄₀N₂O₅
Molecular Weight:556.702
Hs Code.:

Synonyms:4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

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Chemical Property of 4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

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Technology Process of 4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

There total 5 articles about 4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 448961-55-5
4-[2-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethyl-N-benzoyloxy]carbamimidoylphenoxy]butanoic acid ethyl ester

: 448961-56-6
4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

Guidance literature:: In diethylene glycol dimethyl ether; at 110 ℃; for 10h;
DOI:10.1002/jccs.200200014

Reference yield:

: 611-20-1
salicylonitrile

: 448961-56-6
4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / K₂CO₃ / acetonitrile / 11 h / Heating

2: 47 percent / NH₂OH*HCl; K₂CO₃ / ethanol / 11 h / Heating

3: 40 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h / 20 °C

4: 95 percent / bis-(2-methoxy-ethyl) ether / 10 h / 110 °C

With hydroxylamine hydrochloride; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1002/jccs.200200014

Reference yield:

: 2969-81-5
Ethyl 4-bromobutyrate

: 448961-56-6
4-[2-[5-[4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylphenyl]-[1,2,4]oxadiazol-3-yl]phenoxy]butanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / K₂CO₃ / acetonitrile / 11 h / Heating

2: 47 percent / NH₂OH*HCl; K₂CO₃ / ethanol / 11 h / Heating

3: 40 percent / 1,1'-carbonyldiimidazole / tetrahydrofuran / 18 h / 20 °C

4: 95 percent / bis-(2-methoxy-ethyl) ether / 10 h / 110 °C

With hydroxylamine hydrochloride; potassium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; ethanol; diethylene glycol dimethyl ether; acetonitrile;
DOI:10.1002/jccs.200200014