(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Base Information

Chemical Name:(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile
CAS No.:693790-15-7
Molecular Formula:C₃₄H₄₀N₂O₃SSi
Molecular Weight:584.855
Hs Code.:

Synonyms:(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Suppliers and Price of (S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

There total 11 articles about (S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 693790-51-1
methanesulfonic acid (R)-2-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}propyl ester

: 143-33-9,25596-52-5
sodium cyanide

: 693790-15-7
(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Guidance literature:: In dimethyl sulfoxide; at 60 ℃; for 5h;
DOI:10.1139/v03-199

Reference yield:

: 693790-08-8
(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)thiobutyramide

: 693790-15-7
(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

2: 87 percent / (CF₃CO)2O; pyridine / CH₂Cl₂ / 0.33 h / -30 °C

3: 92 percent / AcOH / tetrahydrofuran; H₂O / 14 h / 20 °C

4: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

5: 80 percent / dimethylsulfoxide / 5 h / 60 °C

With pyridine; 2,6-dimethylpyridine; acetic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1139/v03-199

Reference yield:

: 693790-06-6
(S)-4-(tert-butyldiphenylsilanyloxy)-3-(4-methoxybenzyloxy)butyramide

: 693790-15-7
(S)-3-{2-[(S)-3-(tert-butyldiphenylsilanyloxy)-2-(4-methoxybenzyloxy)propyl]thiazol-4-yl}butyronitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / Lawesson's reagent / diisopropyl ether / 0.5 h / 20 °C

2: 73 percent / 2,6-lutidine / CH₂Cl₂ / 14 h / 20 °C

3: 87 percent / (CF₃CO)2O; pyridine / CH₂Cl₂ / 0.33 h / -30 °C

4: 92 percent / AcOH / tetrahydrofuran; H₂O / 14 h / 20 °C

5: 96 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: 80 percent / dimethylsulfoxide / 5 h / 60 °C

With Lawessons reagent; pyridine; 2,6-dimethylpyridine; acetic acid; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide;
DOI:10.1139/v03-199