(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

Base Information

Chemical Name:(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone
CAS No.:152500-29-3
Molecular Formula:C₂₀H₂₈N₂O₄
Molecular Weight:360.453
Hs Code.:

Synonyms:(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

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Technology Process of (S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

There total 10 articles about (S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 152500-21-5
(S)-5-benzyloxymetyl-1-tert-butoxycarbonyl-2-pyrrolidinone

: tert-butoxybis(dimethylamino)methane

: 152500-29-3
(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

Guidance literature:: at 75 ℃; for 3h;
DOI:10.1016/S0040-4020(01)80643-8

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 152500-29-3
(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 4-dimethylaminopyridine / acetonitrile; triethylamine / 3 h / Ambient temperature

2: 99 percent / 3 h / 75 °C

With dmap; In triethylamine; acetonitrile;
DOI:10.1016/S0040-4020(01)80643-8

Reference yield:

: 152500-26-0
(S)-5-(hydroxymethyl)-1-(4-methoxyphenylmethyl)-2-pyrrolidinone

: 152500-29-3
(S)-5-benzyloxymethyl-1-tert-butoxycarbonyl-3-N,N-dimethylaminomethylidene-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaH / dimethylformamide; paraffin / 1 h / Ambient temperature

2: 83 percent / ammonium cerium(IV) nitrate / acetonitrile; H₂O / 2 h / Ambient temperature

3: 98 percent / 4-dimethylaminopyridine / acetonitrile; triethylamine / 3 h / Ambient temperature

4: 99 percent / 3 h / 75 °C

With dmap; ammonium cerium(IV) nitrate; sodium hydride; In water; triethylamine; N,N-dimethyl-formamide; acetonitrile; paraffin;
DOI:10.1016/S0040-4020(01)80643-8