2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Name:2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1201362-27-7
Molecular Formula:C₂₃H₂₂N₄O₂
Molecular Weight:386.453
Hs Code.:

Synonyms:2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 10 articles about 2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201363-02-1
ethyl 2-[4-chloro-2-(phenylamino)pyrimidin-5-yl]-2-methylpropanoate

: 1201364-16-0
(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-aminium trifluoroacetate

: 1201362-27-7
2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 2-ethoxy-ethanol; at 160 ℃; for 48h; Sealed tube;

Reference yield:

: 1201363-02-1
ethyl 2-[4-chloro-2-(phenylamino)pyrimidin-5-yl]-2-methylpropanoate

: 1228561-05-4
C₉H₁₁NO

: 1201362-27-7
2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In 2-ethoxy-ethanol; at 140 ℃;
DOI:10.1016/j.bmcl.2016.08.068

Reference yield:

: 1201363-00-9
ethyl 2-[4-chloro-2-(methylsulfonyl)pyrimidin-5-yl]-2-methylpropanoate

: 1201362-27-7
2-anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

1.2: 1.17 h / 0 - 20 °C

2.1: water; sodium hydrogencarbonate / methanol; N,N-dimethyl-formamide / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 2-ethoxy-ethanol / 48 h / 160 °C / Sealed tube

With water; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol; 2-ethoxy-ethanol; N,N-dimethyl-formamide;