GRA Ex-25

Base Information

• Chemical Name: GRA Ex-25
• CAS No.: 307983-31-9
• Molecular Formula: C₂₉H₃₆F₃N₃O₅
• Molecular Weight: 563.617
• Mol file: 307983-31-9.mol

Synonyms:GRA Ex-25

Chemical Property of GRA Ex-25

Chemical Property:

• Melting Point: 152-154 °C
• Boiling Point: 726.3±60.0 °C(Predicted)
• PKA: 4.29±0.10(Predicted)
• PSA: 107.97000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 6.89260
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

GRAEx-25 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of GRA Ex-25

There total 28 articles about GRA Ex-25 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid methyl ester (307983-40-0) → trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid (307983-31-9)

Guidance literature:

DOI:10.1021/jm058026u

Reference yield:

3-{4-[1-(cis-4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester → 3-{4-[1-(cis-4-tert-butylcyclohexyl)-3-(4-trifluoromethoxy-phenyl)ureidomethyl]benzoylamino}propionic acid (307983-31-9)

Guidance literature:

3-{4-[1-(cis-4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester; With sodium hydroxide; ethanol; water; at 20 ℃; for 16h;

With hydrogenchloride; In water; pH=2;

Reference yield:

3-{4-[1-(cis-4-tert-Butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]-benzoylamino}propionic acid ethyl ester (307989-04-4) → cis-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid (307983-31-9)

Guidance literature:

With sodium hydroxide; In ethanol;

upstream raw materials:

trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid methyl ester

trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

trans-4-[(4-tert-butylcyclohexylimino)methyl]benzoic acid methyl ester

trans-4-[(4-tert-butylcyclohexylamino)methyl]benzoic acid methyl ester