trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

Base Information

Chemical Name:trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester
CAS No.:307989-02-2
Molecular Formula:C₃₁H₄₀F₃N₃O₅
Molecular Weight:591.671
Hs Code.:

Synonyms:trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

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Chemical Property of trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

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Technology Process of trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

There total 9 articles about trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 307989-01-1
trans-4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoic acid

: 4244-84-2
ethyl β-alaninate hydrochloride

: 307989-02-2
trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm058026u

Reference yield:

: 5400-88-4
4-tert-butylcyclohexylamine

: 307989-02-2
trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 23 h / 20 - 100 °C

2: acetonitrile / 16 h / 20 °C

3: aq. NaOH; EtOH / 3 h / 50 °C

4: HOBt; DIPEA / dimethylformamide / 16 h / 20 °C

With sodium hydroxide; ethanol; potassium carbonate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm058026u

Reference yield:

: 307989-24-8
trans-4-[(4-tert-butylcyclohexylimino)methyl]benzoic acid methyl ester

: 307989-02-2
trans-3-{4-[1-(4-tert-butylcyclohexyl)-3-(4-trifluoromethoxyphenyl)ureidomethyl]benzoylamino}propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / acetic acid; NaCNBH₃ / methanol / 0.5 h / 20 °C

2: acetonitrile / 16 h / 20 °C

3: aq. NaOH; EtOH / 3 h / 50 °C

4: HOBt; DIPEA / dimethylformamide / 16 h / 20 °C

With sodium hydroxide; ethanol; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm058026u