2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide

Base Information

• Chemical Name: 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide
• CAS No.: 1009922-41-1
• Molecular Formula: C₁₆H₁₅N₃O₃S
• Molecular Weight: 329.379
• Mol file: 1009922-41-1.mol

Synonyms:2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide

Chemical Property of 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide

There total 2 articles about 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide (98953-13-0) + phenyl isothiocyanate (103-72-0) → 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide (1009922-41-1)

Guidance literature:

In ethanol; for 0.5h; Reflux;

DOI:10.1016/j.bmc.2011.08.063

Reference yield:

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid (4442-54-0) → 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide (1009922-41-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / 120 h / Reflux

3: ethanol / 0.5 h / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2011.08.063

Reference yield: 96.0%

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide (1009922-41-1) → 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol (1338597-15-1)

Guidance literature:

2-(2,3-dihydrobenzo[b][1,4]dioxin-6-carbonyl)-N-phenylhydrazinecarbothioamide; With sodium hydroxide; for 0.5h; Reflux;

With hydrogenchloride; In water; at 20 ℃; pH=3 - 4;

DOI:10.1016/j.bmc.2011.08.063

upstream raw materials:

2,3-dihydro-1,4-benzodioxin-6-carboxylic acid

2,3-dihydrobenzo[b][1,4]dioxine-6-carboxylic acid hydrazide

phenyl isothiocyanate

Downstream raw materials:

3-(benzylthio)-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-phenyl-4H-1,2,4-triazole

3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(2-nitrobenzylthio)-4-phenyl-4H-1,2,4-trazole

3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(3-nitrobenzylthio)-4-phenyl-4H-1,2,4-trazole

3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-(4-nitrobenzylthio)-4-phenyl-4H-1,2,4-trazole