98953-13-0Relevant articles and documents
Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278
Reed, Carson W.,Washecheck, Jordan P.,Quitlag, Marc C.,Jenkins, Matthew T.,Rodriguez, Alice L.,Engers, Darren W.,Blobaum, Anna L.,Jeffrey Conn,Niswender, Colleen M.,Lindsley, Craig W.
, p. 1211 - 1214 (2019/03/26)
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile amide moiety within a series of mGlu7 negative allosteric modulators (NAMs). SAR rapidly
Characterization and Crystal Structure of a Novel Mononuclear Cobalt(II) Complex with Hydrazone Derived from Protocatechuic Acid
Sheng,Wang,Feng,Gao,Zhu
, p. 140 - 144 (2018/03/23)
A novel complex [CoII(L)2·CH3OH] with hydrazone derived from protocatechuic acid (HL=C16H14N2O4) is designed and synthesized. The complex is characterized by single crystal X-ray
Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors
Sun, Juan,Ren, Shen-Zhen,Lu, Xiao-Yuan,Li, Jing-Jing,Shen, Fa-Qian,Xu, Chen,Zhu, Hai-Liang
, p. 2593 - 2600 (2017/04/04)
Focal adhesion kinase (FAK) is an important drug target that plays a fundamental role in mediating signal transduction system. We report herein the discovery of a novel class of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton with