98953-13-0Relevant academic research and scientific papers
Surveying heterocycles as amide bioisosteres within a series of mGlu7 NAMs: Discovery of VU6019278
Reed, Carson W.,Washecheck, Jordan P.,Quitlag, Marc C.,Jenkins, Matthew T.,Rodriguez, Alice L.,Engers, Darren W.,Blobaum, Anna L.,Jeffrey Conn,Niswender, Colleen M.,Lindsley, Craig W.
, p. 1211 - 1214 (2019/03/26)
This letter describes a diversity-oriented library approach to rapidly assess diverse heterocycles as bioisosteric replacements for a metabolically labile amide moiety within a series of mGlu7 negative allosteric modulators (NAMs). SAR rapidly
Synthesis and in vivo Anti-inflammatory Evaluation of Piperazine Derivatives Containing 1,4-Benzodioxan Moiety
Liu, Zhi-Ping,Gong, Chang-Da,Xie, Long-Yan,Du, Xiu-Li,Li, Yang,Qin, Jie
, p. 421 - 426 (2019/07/12)
Six piperazine derivatives 6a–f containing 1,4-benzodioxan moiety have been synthesized and characterized by 1H NMR, ESI-MS and elemental analysis. The structure of 6d was further confirmed by single crystal X-ray diffraction. All these novel c
Characterization and Crystal Structure of a Novel Mononuclear Cobalt(II) Complex with Hydrazone Derived from Protocatechuic Acid
Sheng,Wang,Feng,Gao,Zhu
, p. 140 - 144 (2018/03/23)
A novel complex [CoII(L)2·CH3OH] with hydrazone derived from protocatechuic acid (HL=C16H14N2O4) is designed and synthesized. The complex is characterized by single crystal X-ray
Synthesis, Biological Evaluation, and Molecular Docking of 1,4-Benzodioxan Derivatives as Potential Antibacterial Agents
Liu,Wang,Sheng,Qin,Sun
, p. 2601 - 2610 (2019/04/04)
A series of novel 1,4-benzodioxan derivatives containing Schiff base are synthesized by the method of splicing active substructures. All compounds are assayed for antimicrobial activity. The preliminary results indicate that most of the products demonstrate higher antibacterial activity against Gram-negative bacteria strains than Gram-positive bacteria strains. Compounds 4d and 4m exhibit better antibacterial activity against E. coli (MIC = 0.78 and 0.17 μg/mL), respectively; compound 4g displays better antibacterial activity against P. aeruginosa (MIC = 0.78 μg/mL). Eleven common antibacterial targets are selected for molecular docking of target compounds. The results demonstrate that all target compounds have the strongest binding energy to Tyrosine-tRNA synthetase (-CDOCKER_INTERACTION_ENERGY, kcal/mol: 47.1486 and 47.3776). Therefore, it is speculated that the target compounds can be used as novel tyrosine-tRNA synthetase inhibitors.
Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors
Sun, Juan,Ren, Shen-Zhen,Lu, Xiao-Yuan,Li, Jing-Jing,Shen, Fa-Qian,Xu, Chen,Zhu, Hai-Liang
, p. 2593 - 2600 (2017/04/04)
Focal adhesion kinase (FAK) is an important drug target that plays a fundamental role in mediating signal transduction system. We report herein the discovery of a novel class of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton with
Synthesis, biological evaluation, and molecular docking studies of diacylhydrazine derivatives possessing 1,4-benzodioxan moiety as potential anticancer agents
Wang,Liu,Xu,Sun
, p. 2671 - 2677 (2017/12/26)
A series of diacylhydrazine derivatives containing 1,4-benzodioxan 1-17 has been designed, synthesized and evaluated for antitumor activity. Most of the synthesized compounds demonstrated potent antitumor activity and low toxicity. Compound 10 demonstrate
Oxadiazole-containing piperazine derivative as well as preparation method and use thereof
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, (2016/10/10)
The invention belongs to the technical field of organic synthesis, and particularly relates to an oxadiazole-containing piperazine derivative as well as a preparation method and use thereof. The oxadiazole-containing piperazine derivative provided by the
Synthesis, structure, and urease inhibitory activities of Co(III), Mn(II) and Zn(II) complexes with hydrazone derived from protocatechuic acid
Wang, Cun-Fang,Chen, Zhi-Jian,Zhao, Ke-Dong,Chen, Xiang-Fei,Zhang, Chun-Yang,Sheng, Gui-Hua,Zhu, Hai-Liang
, p. 2656 - 2665 (2016/09/13)
[CoIII(L1)2·H2O]NO3 (1), [MnII(L1)2·H2O] (2), and [ZnII(L1)2·H2O] (3) with a hydrazone derived from protocatechu
Aromatic diacylhydrazine derivatives as a new class of polo-like kinase 1 (PLK1) inhibitors
Sun, Juan,Lv, Peng-Cheng,Guo, Feng-Jiao,Wang, Xin-Yi,Han, Xiao-,Zhang, Yang,Sheng, Gui-Hua,Qian, Shao-Song,Zhu, Hai-Liang
, p. 420 - 426 (2014/06/09)
A novel class of aromatic diacylhydrazine derivatives was designed as PLK1 inhibitors. All the 19 new synthesized compounds were assayed for antitumor activity against the respective cervical cancer cells. In which, nine compounds with better antitumor activities were further tested for their PLK1 inhibitory activity. Last, we have successfully found that compound 7k showed both the promising antitumor activity with IC50 of 0.17 μM against the cervical cancer cells, and also processed the most potent PLK1 inhibitory activity with IC50 of 0.03 μM. In addition, docking simulation also carried out in this study to give a potent prediction binding mode between the small molecule and PKL1 (PDB code: 1umw) protein.
Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent ss-Ketoacyl-acyl carrier protein synthase III (FabH) inhibitor
Song, Xiaoda,Yang, Yushun,Zhao, Jing,Chen, Yangjian
, p. 1110 - 1118 (2014/12/11)
Fatty acid biosynthesis is essential for bacterial survival. ss-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH), is a particularly attractive antibacterial target, since it is central to the initiation of fatty acid biosynthesis. Three series of 2
