9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine

Base Information

• Chemical Name: 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine
• CAS No.: 160053-81-6
• Molecular Formula: C₁₈H₁₈FN₅O₇S
• Molecular Weight: 467.435
• Mol file: 160053-81-6.mol

Synonyms:9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine

Chemical Property of 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine

There total 2 articles about 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) + 2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one (75128-73-3) → 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine (160053-81-6)

Guidance literature:

With dmap; triethylamine; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1080/15257779408013268

Reference yield:

9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(2,4,6-trimethylbenzenesulfonyloxy)-9H-purine (160053-79-2) → 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine (160053-81-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.1 percent Chromat_. / hydrogen / Pd/CaCO₃ / ethanol / 24 h / 70 °C

2: 70 percent / DMAP, Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; hydrogen; triethylamine; Lindlar's catalyst; In ethanol; dichloromethane;

DOI:10.1080/15257779408013268

Reference yield: 19.3%

9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(p-fluorobenzenesulfonyloxy)-9H-purine (160053-81-6) → 9-[(acetoxyethoxy)methyl]guanine (102728-64-3) + 9-<(2-acetoxyethoxy)methyl>-2-acetylamino-9H-purine (120356-09-4) + 2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one (75128-73-3)

Guidance literature:

With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylammonium formate; In 1,4-dioxane; at 90 ℃; for 0.5h;

DOI:10.1080/15257779408013268

upstream raw materials:

4-Fluorobenzenesulfonyl chloride

2-acetylamino-9-(2-acetoxyethoxymethyl)purine-6-one

9-<(2-acetoxyethoxy)methyl>-2-acetylamino-6-(2,4,6-trimethylbenzenesulfonyloxy)-9H-purine

Downstream raw materials:

9-<(2-acetoxyethoxy)methyl>-2-amino-9H-purine

9-[(acetoxyethoxy)methyl]guanine

2-acetylamino-9-<(2-hydroxyethoxy)methyl>-1,9-dihydro-6H-purin-6-one

9-<(2-acetoxyethoxy)methyl>-2-acetylamino-9H-purine