tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate
CAS No.:1370362-98-3
Molecular Formula:C₂₁H₃₄N₂O₆
Molecular Weight:410.511
Hs Code.:

Synonyms:tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

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Chemical Property of tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

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Technology Process of tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

There total 3 articles about tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1370360-21-6
2,4,4-trimethoxybutan-1-amine

: 1370362-98-3
tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/ol3005613

Reference yield:

: 102-52-3
malonaldehydebis(dimethylacetal)

: 1370362-98-3
tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / 3 h / 0 °C / Inert atmosphere; Neat (no solvent)

2: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ol3005613

Reference yield:

: 112890-36-5
2,4,4-trimethoxybutanenitrile

: 1370362-98-3
tert-butyl ((2S)-1-oxo-3-phenyl-1-((2,4,4-trimethoxybutyl)amino)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 1.5 h / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In diethyl ether; dichloromethane;
DOI:10.1021/ol3005613