(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

Base Information

Chemical Name:(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil
CAS No.:352296-29-8
Molecular Formula:C₂₆H₂₈BrF₂N₃O₄
Molecular Weight:564.427
Hs Code.:

Synonyms:(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

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Chemical Property of (R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

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Technology Process of (R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

There total 1 articles about (R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106454-69-7
N-tert-butoxycarbonyl-D-Phenylalaninol

: 352303-66-3
5-bromo-1-(2,6-difluoro-benzyl)-6-methyl-1H-pyrimidine-2,4-dione

: 352296-29-8
(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm049791w

Reference yield:

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 352296-29-8
(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

: 732282-86-9
(R)-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In toluene; at 100 ℃;
DOI:10.1021/jm049791w

Reference yield:

: 352296-29-8
(R)-5-bromo-3-(N-tert-butoxycarbonyl-2-amino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil

: 3-(2-amino-3-phenyl-propyl)-1-(2,6-difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: aq. Ba(OH)2; tetrakis(triphenylphosphine)palladium / benzene; ethanol; 1,2-dimethoxy-ethane / 80 °C

2: TFA / CH₂Cl₂ / 20 °C

With barium dihydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; benzene; 1: Suzuki coupling;
DOI:10.1021/jm049218c