2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

Base Information

Chemical Name:2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide
CAS No.:1026045-48-6
Molecular Formula:C₃₆H₃₉N₃O₄
Molecular Weight:577.723
Hs Code.:

Synonyms:2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

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Chemical Property of 2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

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Technology Process of 2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

There total 7 articles about 2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3261-62-9
2-(p-tolyl)ethylamine

: 1026045-48-6
2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / HOBt, EDCl / tetrahydrofuran / 12 h / 0 °C

2: H₂ / Pd/C / methanol

3: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426

Reference yield:

: 83793-44-6,127862-89-9,135911-27-2,138812-70-1
Z-homophenylalanine

: 1026045-48-6
2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / HOBt, EDCl / tetrahydrofuran / 12 h / 0 °C

2: H₂ / Pd/C / methanol

3: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426

Reference yield:

: 179901-29-2
[(S)-3-Phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-carbamic acid benzyl ester

: 1026045-48-6
2-Benzyl-N-benzyloxy-N'-[(S)-3-phenyl-1-(2-p-tolyl-ethylcarbamoyl)-propyl]-malonamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426