4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

Base Information

Chemical Name:4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile
CAS No.:1309475-08-8
Molecular Formula:C₂₀H₁₆FN₃O
Molecular Weight:333.365
Hs Code.:

Synonyms:4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

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Chemical Property of 4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

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Technology Process of 4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

There total 2 articles about 4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309475-01-1
(R)-4-(8-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

: 352-13-6
4-flourophenylmagnesium bromide

: 1309475-08-8
4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

Guidance literature:: (R)-4-(8-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile; 4-flourophenylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; Cooling with acetone-dry ice; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; Inert atmosphere;

Reference yield:

: 102676-87-9
(R)-(+)-5-(p-cyanophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine

: 1309475-08-8
4-((5R)-8-(4-fluorophenyl)-8-hydroxy-5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butylhydroperoxide; sodium hydrogencarbonate / tetrakis(μ-caprolactamato)dirhodium(Rh-Rh) / 1,2-dichloro-ethane / 40 °C

2.1: diethyl ether; tetrahydrofuran / 20 °C / Cooling with acetone-dry ice; Inert atmosphere

2.2: 20 °C / Inert atmosphere

With tert.-butylhydroperoxide; sodium hydrogencarbonate; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); In tetrahydrofuran; diethyl ether; 1,2-dichloro-ethane;