2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Base Information

Chemical Name:2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride
CAS No.:112151-83-4
Molecular Formula:C₃₈H₅₂N₈O₈*2ClH
Molecular Weight:821.802
Hs Code.:

2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Synonyms:2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Suppliers and Price of 2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

There total 11 articles about 2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (S)-2-((S)-2-{(3S,4S)-4-[(S)-2-[2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-acetylamino]-3-(1H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-propionylamino)-3-phenyl-propionic acid methyl ester

: 112151-83-4
2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at -20 ℃; for 1h;
DOI:10.1021/jm00398a022

Reference yield:

: 2280-66-2
N-tert-butyloxycarbonylalanylphenylalanine methyl ester

: 112151-83-4
2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / ethyl acetate / 1 h / -20 °C

2: 75 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature, 15 h

3: HCl / dioxane / 1 h / Ambient temperature

4: 86 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature

5: 69 percent / hydrogen / 10percent palladium on charcoal / acetic acid; H₂O / 12 h / Ambient temperature

6: 95 percent / HCl / ethyl acetate / 1 h / -20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022

Reference yield:

: 42280-29-5
[(S)-2-tert-butoxycarbonylamino-3-phenylpropanoylamino]acetic acid benzyl ester

: 112151-83-4
2-amino-L-phenylalanylglycyl-L-histidyl-4(S)-amino-3(S)-hydroxy-6-methylheptanoyl-L-alanyl-L-phenylalanine methyl ester dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium on carbon

2: 86 percent / N-hydroxybenzotriazole, diisopropylethylamine, dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 3 h, 2.) room temperature

3: 69 percent / hydrogen / 10percent palladium on charcoal / acetic acid; H₂O / 12 h / Ambient temperature

4: 95 percent / HCl / ethyl acetate / 1 h / -20 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00398a022