(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Base Information

Chemical Name:(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide
CAS No.:336115-13-0
Molecular Formula:C₃₀H₃₃ClN₄O₂
Molecular Weight:517.071
Hs Code.:

Synonyms:(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

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Chemical Property of (±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Chemical Property:

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Technology Process of (±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

There total 14 articles about (±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1314917-44-6
(±)-tert-butyl (3-(N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamido)propyl)carbamate

: 336115-13-0,336113-53-2
(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.11.013

Reference yield:

: 1314917-40-2
(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

: 336115-13-0,336113-53-2
(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1039/c1cc12067k

Reference yield:

: C₃₄H₄₁ClN₆O₄

: 336115-13-0,336113-53-2
(±)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)-4-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine / toluene / Reflux

2: palladium 10% on activated carbon; hydrogen; pyrographite; palladium / methanol / 20 °C / 760.05 Torr

3: triethylamine / dichloromethane / 0 - 20 °C

4: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; pyrographite; palladium; triethylamine; triphenylphosphine; trifluoroacetic acid; In methanol; dichloromethane; toluene; 1: Aza-Wittig reaction;
DOI:10.1039/c1cc12067k