(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

Base Information

Chemical Name:(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate
CAS No.:1314917-40-2
Molecular Formula:C₂₇H₃₅ClN₄O₃
Molecular Weight:499.053
Hs Code.:

Synonyms:(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

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Chemical Property of (±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

Chemical Property:

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Technology Process of (±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

There total 12 articles about (±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1314917-40-2
(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 - 20 °C / Inert atmosphere

2.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

With oxalyl dichloride; sodium tris(acetoxy)borohydride; dimethyl sulfoxide; In dichloromethane; 1,2-dichloro-ethane; 1.1: |Swern Oxidation;
DOI:10.1016/j.bmc.2012.11.013

Reference yield:

: 1314917-39-9
tert-butyl (3-(benzyl(1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

: 1314917-40-2
(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; pyrographite; palladium; In methanol; at 20 ℃; under 760.051 Torr; chemoselective reaction;
DOI:10.1039/c1cc12067k

Reference yield:

: 88333-03-3,10340-91-7
Benzyl isocyanide

: 1314917-40-2
(±)-tert-butyl (3-((1-(3-benzyl-7-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)-2-methylpropyl)amino)propyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 20 °C / Molecular sieve

2: triphenylphosphine / toluene / Reflux

3: palladium 10% on activated carbon; hydrogen; pyrographite; palladium / methanol / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; pyrographite; palladium; triphenylphosphine; In methanol; dichloromethane; toluene; 1: Ugi condensation / 2: Aza-Wittig reaction;
DOI:10.1039/c1cc12067k